T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis

Correlation of T1ρ and T2 Relaxation Times Values with Glycosaminoglycan and Water Content of Articular Cartilage

Changes in T2 relaxation times associated with maturation of the human intervertebral disk.

BACKGROUND AND PURPOSE By calculating T2 relaxation times for intervertebral disks, we tested the hypothesis that disk water concentration increases between the first and second decades of life. MATERIALS AND METHODS In subjects younger than 10 years old (group 1) and subjects between 19 and 20 years old (group 2), a sagittal MR image of the lumbar spine was obtained with a modified 3D fast s...

Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults

Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen concentration in the kn...

T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis

AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees. METHODS Magnetic resonance (MR) images were acquired from 5 subjects scheduled for total knee arthroplasty (TKA) (mean age 70 years) and 20 young healthy control subjects without knee pain (mean age 28.9 years). MR images of T1ρ map...

Knee osteoarthritis diagnosis, treatment and associated factors of progression: Part II

Diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. The potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. Obesity and alignment especially varus malalignment are recognized factors of a progressive disease. Both nonpharmalogical as well as pharmacological modalities of treat...